31 Aug 2021
MGH improves sensitivity of diffuse correlation analysis with new sensor and longer wavelength.
The technique has been the subject of significant recent research, exploiting the increased sensing speeds now possible using current photonics components.
A project at Massachusetts General Hospital (MGH) and MIT Lincoln Laboratory has now tackled one of the remaining hurdles, the low signal to noise ratio (SNR) usually inherent in the technique. The work was published in Neurophotonics.
An ideal clinic-friendly DCS architecture would involve at least 30 millimeters distance between source and detector (SD separation) and illumination wavelengths above 1000 nanometers, according to the researchers. But current limitations in signal-to-noise ratio and photon efficiency hinder developers from reaching these values.
Alterations to detector layout and wavelengths employed have been investigated, but silicon single-photon avalanche detectors (SPADs) have low photon efficiencies, and alternative sensors such as InGaAs cameras are not fast enough for the DCS technique.
The project's solution was to use superconducting nanowire single-photon detectors (SNSPDs), said to be the fastest single-photon detectors for photon counting currently available, and then exploit this enhanced detection capability by operating the DCS technique at 1064 nanometers illumination.
"SNSPDs operate below the boiling point of liquid helium, and consist of a thin film of superconducting material patterned in a compact geometry to create a large pixel with high detection efficiency and a high single-photon sensitivity due to the nanoscale cross-section," noted the project in its published paper.
"They have recently been used in fluorescence lifetime imaging microscopy, but never before in biomedical applications. To our knowledge, this is the first application of SNSPDs in humans to improve DCS performance."
Monitoring intracranial pressure
To test the new approach, an experimental platform was designed in which both SNSPD-DCS and conventional SPAD-DCS were applied to the same patients, using a 1064-nanometer source for the former and a 850-nanometer source for the latter. Measurements were taken from the patient's forehead, and backscattered photons were collected at 5, 25, and 35 millimeters from the source.
Results showed considerable photon gain with the new architecture, with 7 to 8 times more returning photons available at the detector when using 1064 than at 850 nanometers, according to the team. Combined with the inherently higher photon detection efficiency of the SNSPD, the experiment ultimately detected 13-times more photons and demonstrated an average SNR gain of 16 compared to the existing technique.
"The increased SNR of the SNSPD-DCS at 1064 nm allowed us to resolve clear arterial pulsation at 20 hertz at a 25 millimeter SD separation in all subjects," recorded the project, which anticipates new clinical uses arising from the modified technique.
"Being able to acquire pulsatile blood flow at high frequency with low SNR at separations of 25 millimeters or more is important in applications where that pulsatile blood flow is used to estimate intracranial pressure non-invasively."