17 Apr 2013
Economy optics find a new life in speedy technique for on-the-spot bioanalytics.
Aman Russom, senior lecturer at the School of Biotechnology at KTH Royal Institute of Technology in Stockholm, says that his research team converted a commercial DVD drive into a laser scanning microscope that can analyze blood and perform cellular imaging with one-micrometre resolution.
The development creates the possibility of an inexpensive and simple-to-use tool that could have far-reaching benefits in health care in the developing world.
“With an ordinary DVD player, we have created a cheap analytical tool for DNA, RNA, proteins and even entire cells,” says Russom. The so-called "Lab-on-DVD" technology makes it possible to complete an HIV test in just a few minutes, he says.
The Lab-on-DVD reaps 30 years of research and development on optical storage technology to create an alternative to flow cytometry, the standard equipment for hospitals.
Flow cytometry units can cost upwards of USD 30,000, excluding maintenance. By contrast, mass-produced Lab-on-DVD units could be made available for less than USD 200, Russom says. And unlike the bulky and technically-complex flow cytometry instruments, a Lab-on-DVD would be portable and require less training to operate.
“The low cost of the technology makes it suitable as a diagnostic and analytical tool in clinical practice close to the patient,” Russom says. “And because it delivers extremely fast analysis, the patient does not need to go home and wait for a response. They can get it right on the first visit to a doctor.”
The research was partly funded by the EU Seventh Framework Programme, FP7. The researchers' work was highlighted in April 2013 in Nature Photonics.
About the Author
Mattew peach is a contributing editor to optics.org.