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Laser assisted: discovery of 3D structure of Cathepsin B.
3D structure of Cathepsin B. In the "closed" conformation, an occluding loop (rigid segment: beige; flexible segment: red) blocks access to the substrate site. The propeptide binding shifts the flexible part of the loop in such a manner that the reactive partners of cathepsin B can reach the substrate site. Credit: Science Express, DOI: 10.1126/science.1229
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