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| Time-lapse single-molecule orientation-localization microscopy (SMOLM) of amyloid beta (Aβ42) fibrils undergoing remodeling, taken over 10 minutes, shown as a multi-colored mosaic. Transiently binding and flashing Nile blue (NB) molecules enable the nanoscale architectures of growing and decaying regions in fibrils to be visualized as these multicolored forks. Credit: WashU/Lew lab. |
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