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Molecular model
Top: the schematic model of Wnt regulation of cancer metabolism and angiogenesis through the PDK1 enzyme, as deduced by the Irvine-led team. Bottom: staining of normal human small intestine (PDK1) and normal human colon shows correlations between high levels of Wnt signaling, PDK1 activity, and HIF1α levels. Credit: Waterman et al, The EMBO Journal.
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