A Postdoctoral research fellowship in the area of In Vivo neuroimaging is available in the TNNC lab led by Dr. Xin YU (tnnc.mgh.harvard.edu) at the Massachusetts General Hospital (MGH) in the Martinos Center for Biomedical Imaging. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new neuroimaging technologies with applications in basic and clinical research.
The fellowship will focus on the development of advanced in vivo MR compatible and implantable optical imaging devices, including fiber photometry and multi-photon imaging technologies, in the existing 14T MR scanner environment. The specific aim of the fellowship can be tailored to meet individual goals, which will provide an opportunity to build clinical, research, and publication experience.
Representative recent publications from the lab include:
· Sobczak F, Pais-Roldán P, Takahashi K, Yu, X, Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation, eLife, (In press).
· Pais-Roldán P, Takahashi K, Sobczak F, Chen Y, Zhao X, Zeng H, Jiang Y, Yu X. Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6875-6882. PMID: 32139609.
· Chen X, Sobczak F, Chen Y, Jiang Y, Qian C, Lu Z, Ayata C, Logothetis NK, Yu X. Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus. Nat Communications. 2019 11 20; 10(1):5239. PMID: 31748553.
· He, Y., Wang, M., Chen, X., Pohmann, R., Polimeni, J.R., Scheffler, K., Rosen, B.R., Kleinfeld, D., and Yu, X. (2018). Ultra-slow single vessel BOLD and CBV-based fMRI spatiotemporal dynamics and their correlation with neuronal intracellular calcium signals. Neuron, 97:1-15. doi/10.1016/j.neuron.2018.01.025
· Wang, M., He, Y., Sejnowski, T.J., and Yu, X. (2018). Brain-state dependent astrocytic Ca2+ signals are coupled to both positive and negative BOLD-fMRI signals. Proc Natl Acad Sci U S A, 115(7):E1647-E56. doi: 10.1073/pnas.1711692115. PubMed PMID: 29382752; PMCID: PMC5816146.
· Yu X*, Qian C., Chen D-Y, Dodd S, and Koretsky A*, Deciphering laminar-specific neural inputs with line-scanning fMRI, Nature Methods, 11, 55–58. (2014) * corresponding authors.
· Yu X*, He Y, Wang M, Merkle H, Dodd SJ, Silva AC, Koretsky A* Sensory and optogenetically driven single-vessel fMRI, Nature Methods 13 (4) 337-340. (2016) *Corresponding author.